Obesity

• National Crisis
• Over passed decade number of over weight increased from 12%-70%(61million American)
• Morbid Obesity BMI 40 Or 35 (BMI kg/m2)
• 140,000 procedures for MO in USA

Risks of MO

• Females 40y and older loss 7.1 years of their life span, Males 40y and older lose 5.8 years
• 300,000 adults die of MO problems in USA
• Uterine CA 5.4,Gall B ca 3.6,Cervical ca 2.4 Ovarian ca 1.6,breast ca 1.5 prostate ca 1.3 colorectal 1,7

Treatment Options

• Non Surgical (not effective on long term)
• Bariatric Research
• Surgical

Ghrelin - produced by the stomach and controls appetite

• Hormone secreted predominantly by gastric cells; recognized in 1999 as a mediator of growth-hormone release(1)
• Increases an hour or two before a meal and goes into a “trough-like” level after eating(2)
• Weight loss of 17 percent of body weight from dieting is associated with a 24 percent increase in the 24-hour ghrelin profile(2)
• Activated by the presence of dietary lipids(3)